In view of China's cosmetics industry, cosmetic packaging bottle sterilization disinfection field for many years, used old process defects, reference to international advanced disinfection industry, according to the Ministry of health to develop the "GMP test guide" and "disinfection technical specifications" requirement, design and manufacture of "JZCF-B" series of packaging container ozone disinfection system, the disinfection effect is obvious. Cosmetic packaging containers need advanced analysis of sterilization process.
1. Principle of ozone sterilization
The sterilizing of ozone belongs to the biochemical oxidation reaction. Ozone oxidation and decomposition to bacteria oxidation of glucose enzyme; can also react with bacteria or viruses, destroying the cell wall and RNA, DNA, protein, RNA, decomposition of lipid and polysaccharide polymer, the metabolism of bacteria growth and reproduction process can penetrate cell destruction; membrane organization, LPS induced invasion within the cell membrane in the outer membrane lipoprotein and inside, make the cell permeability distortion, leading to cell death and dissolution, the death of bacteria in vivo genetic, parasitic bacteria, parasitic virus particles, phage, mycoplasma and pyrogen (bacteria metabolites, endotoxin) dissolved degeneration and death. The principle of the action of microorganisms in aseptic technique can be divided into three kinds of antibacterial, bactericidal and bacteriolytic agent, application of ozone for sterilization is.
In the "disinfection technical specification" issued by the Ministry of health in 1991, the principle of ozone sterilization is also introduced.
"Scientific research has shown that ozone has a very strong bactericidal effect." Ozone is unstable at room temperature and atmospheric pressure. It decomposes quickly into oxygen (O2) and single oxygen atom (O). The latter has strong activity and has strong oxidation effect on bacteria. Ozone oxidizes the enzyme necessary for the oxidation of glucose inside the bacteria, thereby destroying the cell membrane and killing it. The excess oxygen atoms will recombine itself into an ordinary oxygen molecule (O2), and there is no toxic residue. Therefore, it is called "pollution-free disinfectant". It not only has strong killing ability to all kinds of bacteria, including hepatitis virus, Escherichia coli, green strong bacilli and heterozygous bacteria, but also is effective for killing mould.